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Associated laboratories : INRA - Agro Paris’Tech


INRA-AgroParisTech, Grignon - Research

• Signal Transduction in Bacteria
. Research projects : Cellular signaling and regulation networks based on protein phosphorylation in Bacillus subtilis, developmental phenomena in the stationary phase, metabolic engineering of B. subtilis for white biotechnology production of platform chemicals.
. Approaches : classical genetics, biochemistry and molecular biology, global analyses of proteome and phosphoproteome (using in-house mass spectrometry platform PAPSSO, or via collaboration with the Proteome Center Tübingen), in silico optimization of the metabolic network in collaboration with Dr. Vincent Fromion (INRA).
Contact : Prof. Ivan Mijakovic

• Regulatory mechanisms, regulatory networks and integrated physiology in bacteria
. Research projects : Genetic regulation network of the central metabolism and its integrated implementation during adaptation to environmental shifts in the Bacillus subtilis model species ; Growth rate management at the transcriptional, translational and physiological levels ; Noise in gene expression ; Model-driven synthetic gene circuits.
. Approaches : Specific analyses of control mechanisms, global analyses ("-omics") among which real time monitoring of promoter activities ("Live Cell Array") and data integration, and modeling (through collaborations, notably with Vincent Fromion’s team at INRA, Jouy).
Contact : Stéphane Aymerich

INRA-AgroParisTech, Jouy-en-Josas - GABI
Génétique Animale et Biologie Intégrative

• Populations, Statistics & Genome (PSGen)
. Population genetics : Genetics of chromosomal segments to model the bases of the selection response, analysis of linkage disequilibrium, identifying signatures of selection during the history of populations.
. Statistical genetics : Bayesian approach of the mixed model, analytical methods for transcriptomics and gene network data.
. Genetic resource engineering : Analyzis of polymorphism and genetic structure of populations in a wide variety of situations by combining genealogical and molecular information. Analysis of the impact of selection on the genetic variability of populations along with the efficacy of conservation measures, in situ or in cryobanks.
. Analysis of functional variation : Analyzing precisely genes with visible effects, such as coloration genes, exploring phenotypic variation, identifying causal mutations, concluding on the evolutionary history of species.
Analysis of gene expression, functions associated with animal adaptation or health, including thermotolerance, immunity and robustness.
Contacts : Frédéric Hospital & Denis Laloë